Robert M. Badeau

Robert Badeau

Program Director of Health Science Program, Assistant Professor of Biology

Phone: 260.422.5561, ext. 3475

Cell Phone: 603.767.3869

Email: RMBadeau@indianatech.edu

Office: Zollner Engineering Center


Class Information

BIO 1000: Introductory Biology
BIO 1100: Anatomy and Physiology
PH 1000: Physical Science


College/School

College of Arts and Sciences


Academic Degrees

Ph.D. Molecular Medicine; University of Helsinki
M.Sc. Molecular and Cellular Pathobiology; Wake Forest University
B.Sc. Cellular and Developmental Biology; Purdue University


Selected Publications/Presentations

  1. Badeau RM, Immonen H, Honka MJ, Juonala M, Barnum K, Hannukainen JC, Nuutila P. (2018) Circulating glycoprotein N-acetyl glucosamine residue signatures indicative of systemic acute-phase reactants and lactate concentrations associate with hepatic insulin resistance in bariatric surgery patients. Under submission.
  2. Badeau RM, Honka MJ, Bucci M, Iozzo P, Eriksson JG, Nuutila P. (2017) Circulating docosahexaenoic acid associates with insulin-dependent skeletal muscle and whole body glucose uptake in older women born from normal weight mothers. Nutrients, 9, 110
  3. Bucci M, Huovinen V, Guzzardi MA, Koskinen S, Raiko JR, Lipponen H, Ahsan S, Badeau RM, Honka MJ, Koffert J, Savisto N, Salonen MK, Andersson J, Kullberg J, Sandboge S, Iozzo P, Eriksson JG, Nuutila P. (2015) Resistance training improves skeletal muscle insulin sensitivity in elderly offspring of overweight and obese mothers. Diabetolgia, 59:77-86.
  4. Bucci M, Huovinen V, Guzzardi MA, Koskinen S, Raiko J, Lipponen H, Badeau RM, Sarja N, Salonen MK, Andersson J, Kullberg J, Sandboge S, Iozzo P, Eriksson JG, Nuutila P. (2015) Maternal obesity and telomere length associate with skeletal muscle insulin resistance which is reversed by exercise training in elderly women. Diabetologia, 58.
  5. Badeau RM, Honka MJ, Immonen H, Hannukainen JC, Soininen P, Kangas AJ, Ala-Korpela M, Tontonoz P, Nuutila P. (2015) VLDL and HDL associate with hepatic glucose uptake, production, and the liver X receptor and its targets in morbidly obese before and after rapid weight-loss interventions. Atherosclerosis 241: e106.
  6. Honka MJ, Bucci M, Andersson J, Huovinen V, Guzzardi MA, Sandboge S, Savisto N, Salonen MK, Badeau RM, Parkkola R, Kullberg J, Iozzo P, Eriksson JG, Nuutila P. (2016) Resistance training enhances insulin suppression of endogenous glucose production in elderly women. J. Appl. Physiol. 5:120:633-639.
  7. Bucci M, Karmi AC, Iozzo P, Fielding BA, Viljanen A, Badeau RM, Borra R, Lepomäki V, Pham T, Hannukainen JC, Haaparanta-Solin M, Viljanen T, Parkkola R, Frayn KN, Nuutila P. (2016) Enhanced fatty acid uptake in visceral adipose tissue is not reversed by weight loss in obese individuals with the metabolic syndrome. Diabetolgia, 58:158-164.
  8. Solomäki SP, Kemppainen J, Aho H, Hohenthal U, Kain R, Koivuviita N, Badeau RM, Seppänen M, Silvoniemi A, Roivainen A, Pirilä L. (2014) Widespread vascular inflammation in a patient with antineutrophil cytoplasmic antibody-associated vasculatis as detected by positron emission tomography. European Journal of Nuclear Medicine and Molecular Imaging, 41:2167-2168.
  9. Vogel A, Scheidt HA, Feller SE, Metso J, Badeau RM, Tikkanen MJ, Wähälä K, Jauhiainen M, Huster D. (2014) The orientation and dynamics of estradiol and estradiol oleate in lipid membranes and HDL disc models. Biophysical Journal, 107:114-125.
  10. Huovinen V, Saunavaara V, Kiviranta R, Tarkia M, Honka H, Stark C, Laine J, Linderborg K, Tuomikoski P, Badeau RM, Knuuti J, Nuutila P, Parkkola R. (2014) Vertebral bone marrow glucose uptake is inversely associated with bone marrow fat in diabetic and healthy pigs: [18F]FDG-PET and MRI study. Bone, 61:33-38.
  11. Badeau RM, Honka M-J, Lautamäki R, Stewart M, Kangas AJ, Soininen P, et al. (2014) Systemic metabolic markers and myocardial glucose uptake in type 2 diabetic and coronary artery dis-ease patients treated for 16-weeks with Rosiglitazone, a PPARγ agonist. Annals of Medicine, 46:18-23.
  12. Badeau RM, Metso J, Kovanen PT, Lee-Rueckert M, Tikkanen MJ, Jauhiainen M. (2013) The impact of gender and serum estradiol levels on HDL-mediated reverse cholesterol transport. European Journal of Clinical Investigation, 43:317-323.
  13. Klingenberg R, Gerdes N, Badeau RM, Gisterå, A, Strodthoff D, Ketelhuth DF, Lundberg AM, Rudling M, Nilsson SK, Olivecrona G, Zoller S, Lohmann C, Lüscher TF, Jauhiainen M, Sparwas-ser T, Hansson GK. (2013) Depletion of FOXP3+ regulatory T cells promotes hypercholesterole-mia and atherosclerosis. The Journal of Clinical Investigation, 123:1323-1334.
  14. Maranghi M, Hiukka A, Badeau R, Sundvall J, Jauhiainen M, Taskinen MR. (2011) Macrophage cholesterol efflux to plasma and HDL in subjects with low and high homocysteine levels: A FIELD substudy. Atherosclerosis, 219:259-265.
  15. Scheidt HA, Badeau RM, Huster D. (2010) Investigating the membrane orientation and trans-versal distribution of 17beta-estradiol in lipid membranes by solid-state NMR. Chemistry of Physics of Lipids, 163:356-361.
  16. Badeau RM, Metso J, Wähälä K, Tikkanen MJ, Jauhiainen M. (2009) Human macrophage cho-lesterol efflux is enhanced by HDL-associated estradiol fatty acyl esters. J Steroid Biochem Mol Biol, 116:44-49.
  17. Badeau RM, Metso J, Wähälä K, Tikkanen MJ, Jauhiainen M. (2009) Concerted scavenger receptor-BI and estrogen receptor-dependent 17beta estradiol uptake and choleterol efflux mediated by estradiol fatty acyl ester-enriched high-density lipoprotein particles in human THP1 macrophages. Atherosclerosis Supplements 10 (2)
  18. Badeau MH, Badeau R, Jauhiainen M, Tikkanen MJ. (2008) Steroid hormone-fatty acid esters and bone. J Bone Miner Res, 23:1866-1867.
  19. Badeau RM, Metso J, Tikkanen MJ, Jauhiainen M. (2007) High-density lipoprotein-associated 17β-estradiol fatty acyl ester uptake by Fu5AH hepatoma cells: Implications for the roles of scavenger receptor class B, type I and the low-density lipoprotein receptor. Biochim Biophys Acta, 1771: 1329-1334. IF: 4.66.
  20. Badeau RM, Metso J, Tikkanen MJ, Jauhiainen M. (2007) Lipoprotein receptor-mediated cellu-lar uptake of HDL-associated estradiol fatty acyl esters. Chemistry and Physics of Lipids. 149.
  21. Lee JY, Badeau RM, Mulya A, Boudyguina E, Gebre AK, Smith TL, Parks JS. (2007) Functional LCAT deficiency in human apolipoprotein A-I transgenic, SR-BI knockout mice. J Lipid Res, 48:1052-1061. IF: 4.39.
  22. Badeau RM, Jauhiainen M, Metso J, Nikander E, Tikkanen MJ, Ylikorkala O, Mikkola TS. (2007) Effect of isolated isoflavone supplementation on ABCA1-dependent cholesterol efflux potential in postmenopausal women. Menopause, 14:1-6.
  23. Liu G, Badeau RM, Tanimura A, Talamo BR. (2006) Odorant receptors directly activate phos-pholipase C/inositol-1,4,5-trisphosphate coupled to calcium influx in Odora cells. J Neuro-chem., 96:1591-1605.
  24. Badeau RM, Nikander E, Jauhiainen M, Tikkanen M, Mikkola TS. (2005) Macrophage ABCA-I cholesterol efflux to serum from equol-producing and non-equol producing post-menopausal women treated with isoflavone tablets. Menopause, 12.

Additional Information

Dr. Badeau’s research interest is in human cardiometabolic disease pathogenesis. He has over four years of clinical research experience using nuclear medicine imaging technologies, including positron emission tomography and computed tomography, and high-throughput metabolomic technologies. He is on the fore-front of modern obesity research by working in collaboration to develop therapeutic interventions to ameliorate insulin resistance severity in morbidly obese individuals. He also serves as an active member of the American Heart Association on the Council of Lifestyle and Cardiometabolic Health and also with the American Diabetes Association.